Towards the introduction of the ‘Immunoscore’ in the classification of malignant tumours
Identifieur interne : 003C97 ( Main/Exploration ); précédent : 003C96; suivant : 003C98Towards the introduction of the ‘Immunoscore’ in the classification of malignant tumours
Auteurs : Jérôme Galon [France] ; Bernhard Mlecnik [France] ; Gabriela Bindea [France] ; Helen K. Angell [France] ; Anne Berger [France] ; Christine Lagorce [France] ; Alessandro Lugli [Suisse] ; Inti Zlobec [Suisse] ; Arndt Hartmann [Allemagne] ; Carlo Bifulco [États-Unis] ; Iris D. Nagtegaal [Pays-Bas] ; Richard Palmqvist [Suède] ; Giuseppe V. Masucci [Suède] ; Gerardo Botti [Italie] ; Fabiana Tatangelo [Italie] ; Paolo Delrio [Italie] ; Michele Maio [Italie] ; Luigi Laghi [Italie] ; Fabio Grizzi [Italie] ; Martin Asslaber [Autriche] ; Corrado D'Arrigo [Royaume-Uni] ; Fernando Vidal-Vanaclocha [Espagne] ; Eva Zavadova [République tchèque] ; Lotfi Chouchane [Qatar] ; Pamela S. Ohashi [Canada] ; Sara Hafezi-Bakhtiari [Canada] ; Bradly G. Wouters [Canada] ; Michael Roehrl [Canada] ; Linh Nguyen [Canada] ; Yutaka Kawakami [Japon] ; Shoichi Hazama [Japon] ; Kiyotaka Okuno [Japon] ; Shuji Ogino [États-Unis] ; Peter Gibbs [Australie] ; Paul Waring [Australie] ; Noriyuki Sato [Japon] ; Toshihiko Torigoe [Japon] ; Kyogo Itoh [Japon] ; Prabhu S. Patel [Inde] ; Shilin N. Shukla [Inde] ; Yili Wang [République populaire de Chine] ; Scott Kopetz [États-Unis] ; Frank A. Sinicrope [États-Unis] ; Viorel Scripcariu [Roumanie] ; Paolo A. Ascierto [Italie] ; Francesco M. Marincola [Qatar] ; Bernard A. Fox [États-Unis] ; Franck Pagès [France]Source :
- The Journal of Pathology [ 0022-3417 ] ; 2014-01.
Abstract
The American Joint Committee on Cancer/Union Internationale Contre le Cancer (AJCC/UICC) TNM staging system provides the most reliable guidelines for the routine prognostication and treatment of colorectal carcinoma. This traditional tumour staging summarizes data on tumour burden (T), the presence of cancer cells in draining and regional lymph nodes (N) and evidence for distant metastases (M). However, it is now recognized that the clinical outcome can vary significantly among patients within the same stage. The current classification provides limited prognostic information and does not predict response to therapy. Multiple ways to classify cancer and to distinguish different subtypes of colorectal cancer have been proposed, including morphology, cell origin, molecular pathways, mutation status and gene expression‐based stratification. These parameters rely on tumour‐cell characteristics. Extensive literature has investigated the host immune response against cancer and demonstrated the prognostic impact of the in situ immune cell infiltrate in tumours. A methodology named ‘Immunoscore’ has been defined to quantify the in situ immune infiltrate. In colorectal cancer, the Immunoscore may add to the significance of the current AJCC/UICC TNM classification, since it has been demonstrated to be a prognostic factor superior to the AJCC/UICC TNM classification. An international consortium has been initiated to validate and promote the Immunoscore in routine clinical settings. The results of this international consortium may result in the implementation of the Immunoscore as a new component for the classification of cancer, designated TNM‐I (TNM‐Immune). © 2013 The Authors. Journal of Pathology published by John Wiley & Sons Ltd on behalf of Pathological Society of Great Britain and Ireland.
Url:
DOI: 10.1002/path.4287
Affiliations:
- Allemagne, Australie, Autriche, Canada, Espagne, France, Inde, Italie, Japon, Pays-Bas, Qatar, Roumanie, Royaume-Uni, République populaire de Chine, République tchèque, Suisse, Suède, États-Unis
- Bohême centrale, Canton de Berne, Communauté de Madrid, Lombardie, Massachusetts, Oregon, Région de Kantō, Svealand, Texas, Victoria (État), Île-de-France
- Berne, Bobigny, Boston, Houston, Madrid, Melbourne, Milan, Paris, Portland, Prague, Stockholm, Tokyo
- Université Paris-Descartes, Université de Berne, Université de Melbourne
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Le document en format XML
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Studio e la Cura dei Tumouri, ‘Fondazione G Pascale’, Naples</wicri:regionArea><wicri:noRegion>Naples</wicri:noRegion></affiliation></author><author><name sortKey="Delrio, Paolo" sort="Delrio, Paolo" uniqKey="Delrio P" first="Paolo" last="Delrio">Paolo Delrio</name><affiliation wicri:level="1"><country xml:lang="fr">Italie</country><wicri:regionArea>Colorectal Surgery Department, Istituto Nazionale per lo Studio e la Cura dei Tumouri, ‘Fondazione G Pascale’, Naples</wicri:regionArea><wicri:noRegion>Naples</wicri:noRegion></affiliation></author><author><name sortKey="Maio, Michele" sort="Maio, Michele" uniqKey="Maio M" first="Michele" last="Maio">Michele Maio</name><affiliation wicri:level="1"><country xml:lang="fr">Italie</country><wicri:regionArea>Division of Medical Oncology and Immunotherapy, University Hospital of Siena, Istituto Toscano Tumouri, Siena</wicri:regionArea><wicri:noRegion>Siena</wicri:noRegion></affiliation></author><author><name sortKey="Laghi, Luigi" sort="Laghi, Luigi" uniqKey="Laghi L" first="Luigi" last="Laghi">Luigi Laghi</name><affiliation wicri:level="3"><country xml:lang="fr">Italie</country><wicri:regionArea>Molecular Gastroenterology and Department of Gastroenterology, Humanitas Clinical and Research Centre, Rozzano, Milan</wicri:regionArea><placeName><settlement type="city">Milan</settlement><region nuts="2">Lombardie</region></placeName></affiliation></author><author><name sortKey="Grizzi, Fabio" sort="Grizzi, Fabio" uniqKey="Grizzi F" first="Fabio" last="Grizzi">Fabio Grizzi</name><affiliation wicri:level="3"><country xml:lang="fr">Italie</country><wicri:regionArea>Molecular Gastroenterology and Department of Gastroenterology, Humanitas Clinical and Research Centre, Rozzano, Milan</wicri:regionArea><placeName><settlement type="city">Milan</settlement><region nuts="2">Lombardie</region></placeName></affiliation></author><author><name sortKey="Asslaber, Martin" sort="Asslaber, Martin" uniqKey="Asslaber M" first="Martin" last="Asslaber">Martin Asslaber</name><affiliation wicri:level="1"><country xml:lang="fr">Autriche</country><wicri:regionArea>Institute of Pathology, Medical University of Graz</wicri:regionArea><wicri:noRegion>Medical University of Graz</wicri:noRegion></affiliation></author><author><name sortKey="D Arrigo, Corrado" sort="D Arrigo, Corrado" uniqKey="D Arrigo C" first="Corrado" last="D'Arrigo">Corrado D'Arrigo</name><affiliation wicri:level="1"><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Department of Histopathology, Dorset County Hospital, Dorchester</wicri:regionArea><wicri:noRegion>Dorchester</wicri:noRegion></affiliation></author><author><name sortKey="Vidal Anaclocha, Fernando" sort="Vidal Anaclocha, Fernando" uniqKey="Vidal Anaclocha F" first="Fernando" last="Vidal-Vanaclocha">Fernando Vidal-Vanaclocha</name><affiliation wicri:level="3"><country xml:lang="fr">Espagne</country><wicri:regionArea>CEU‐San Pablo University School of Medicine and HM Hospital of Madrid Scientific Foundation, Institute of Applied Molecular Medicine (IMMA), Madrid</wicri:regionArea><placeName><settlement type="city">Madrid</settlement><region nuts="2" type="region">Communauté de Madrid</region></placeName></affiliation></author><author><name sortKey="Zavadova, Eva" sort="Zavadova, Eva" uniqKey="Zavadova E" first="Eva" last="Zavadova">Eva Zavadova</name><affiliation wicri:level="3"><country xml:lang="fr">République tchèque</country><wicri:regionArea>Department of Oncology, Charles University in Prague, First Faculty of Medicine, Department of Oncology of the First Faculty of Medicine and General Hospital, Prague</wicri:regionArea><placeName><settlement type="city">Prague</settlement><region type="région" nuts="2">Bohême centrale</region></placeName></affiliation></author><author><name sortKey="Chouchane, Lotfi" sort="Chouchane, Lotfi" uniqKey="Chouchane L" first="Lotfi" last="Chouchane">Lotfi Chouchane</name><affiliation wicri:level="1"><country xml:lang="fr">Qatar</country><wicri:regionArea>Weill Cornell Medical College, Doha</wicri:regionArea><wicri:noRegion>Doha</wicri:noRegion></affiliation></author><author><name sortKey="Ohashi, Pamela S" sort="Ohashi, Pamela S" uniqKey="Ohashi P" first="Pamela S" last="Ohashi">Pamela S. Ohashi</name><affiliation wicri:level="1"><country xml:lang="fr">Canada</country><wicri:regionArea>Ontario Cancer Institute and Campbell Family Institute for Cancer Research, Princess Margaret Hospital, University Health Network, ON, Toronto</wicri:regionArea><wicri:noRegion>Toronto</wicri:noRegion></affiliation></author><author><name sortKey="Hafezi Akhtiari, Sara" sort="Hafezi Akhtiari, Sara" uniqKey="Hafezi Akhtiari S" first="Sara" last="Hafezi-Bakhtiari">Sara Hafezi-Bakhtiari</name><affiliation wicri:level="1"><country xml:lang="fr">Canada</country><wicri:regionArea>Department of Pathology and Laboratory Medicine, University Health Network, ON, Toronto</wicri:regionArea><wicri:noRegion>Toronto</wicri:noRegion></affiliation></author><author><name sortKey="Wouters, Bradly G" sort="Wouters, Bradly G" uniqKey="Wouters B" first="Bradly G" last="Wouters">Bradly G. Wouters</name><affiliation wicri:level="1"><country xml:lang="fr">Canada</country><wicri:regionArea>Department of Pathology and Laboratory Medicine, University Health Network, ON, Toronto</wicri:regionArea><wicri:noRegion>Toronto</wicri:noRegion></affiliation></author><author><name sortKey="Roehrl, Michael" sort="Roehrl, Michael" uniqKey="Roehrl M" first="Michael" last="Roehrl">Michael Roehrl</name><affiliation wicri:level="1"><country xml:lang="fr">Canada</country><wicri:regionArea>UHN Program in BioSpecimen Sciences, University Health Network, ON, Toronto</wicri:regionArea><wicri:noRegion>Toronto</wicri:noRegion></affiliation></author><author><name sortKey="Nguyen, Linh" sort="Nguyen, Linh" uniqKey="Nguyen L" first="Linh" last="Nguyen">Linh Nguyen</name><affiliation wicri:level="1"><country xml:lang="fr">Canada</country><wicri:regionArea>Campbell Family Institute for Breast Cancer Research, Princess Margaret Cancer Centre, University Health Network, ON, Toronto</wicri:regionArea><wicri:noRegion>Toronto</wicri:noRegion></affiliation></author><author><name sortKey="Kawakami, Yutaka" sort="Kawakami, Yutaka" uniqKey="Kawakami Y" first="Yutaka" last="Kawakami">Yutaka Kawakami</name><affiliation wicri:level="3"><country xml:lang="fr">Japon</country><wicri:regionArea>Division of Cellular Signalling, Institute for Advanced Medical Research, Keio University School of Medicine, Tokyo</wicri:regionArea><placeName><settlement type="city">Tokyo</settlement><region type="région">Région de Kantō</region></placeName></affiliation></author><author><name sortKey="Hazama, Shoichi" sort="Hazama, Shoichi" uniqKey="Hazama S" first="Shoichi" last="Hazama">Shoichi Hazama</name><affiliation wicri:level="1"><country xml:lang="fr">Japon</country><wicri:regionArea>Department of Digestive Surgery and Surgical Oncology, Yamaguchi University Graduate School of Medicine</wicri:regionArea><wicri:noRegion>Yamaguchi University Graduate School of Medicine</wicri:noRegion></affiliation></author><author><name sortKey="Okuno, Kiyotaka" sort="Okuno, Kiyotaka" uniqKey="Okuno K" first="Kiyotaka" last="Okuno">Kiyotaka Okuno</name><affiliation wicri:level="1"><country xml:lang="fr">Japon</country><wicri:regionArea>Department of Surgery, Kinki University School of Medicine, Osaka‐sayama</wicri:regionArea><wicri:noRegion>Osaka‐sayama</wicri:noRegion></affiliation></author><author><name sortKey="Ogino, Shuji" sort="Ogino, Shuji" uniqKey="Ogino S" first="Shuji" last="Ogino">Shuji Ogino</name><affiliation wicri:level="3"><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Pathology, Brigham and Women's Hospital, Harvard Medical School and Department of Medical Oncology, Dana‐Farber Cancer Institute, MA, Boston</wicri:regionArea><placeName><settlement type="city">Boston</settlement><region type="state">Massachusetts</region></placeName></affiliation></author><author><name sortKey="Gibbs, Peter" sort="Gibbs, Peter" uniqKey="Gibbs P" first="Peter" last="Gibbs">Peter Gibbs</name><affiliation wicri:level="1"><country xml:lang="fr">Australie</country><wicri:regionArea>Department of Medical Oncology, Royal Melbourne Hospital</wicri:regionArea><wicri:noRegion>Royal Melbourne Hospital</wicri:noRegion></affiliation></author><author><name sortKey="Waring, Paul" sort="Waring, Paul" uniqKey="Waring P" first="Paul" last="Waring">Paul Waring</name><affiliation wicri:level="4"><country xml:lang="fr">Australie</country><wicri:regionArea>Department of Pathology, University of Melbourne</wicri:regionArea><placeName><settlement type="city">Melbourne</settlement><region type="état">Victoria (État)</region></placeName><orgName type="university">Université de Melbourne</orgName></affiliation></author><author><name sortKey="Sato, Noriyuki" sort="Sato, Noriyuki" uniqKey="Sato N" first="Noriyuki" last="Sato">Noriyuki Sato</name><affiliation wicri:level="1"><country xml:lang="fr">Japon</country><wicri:regionArea>Department of Pathology, Sapporo Medical University School of Medicine</wicri:regionArea><wicri:noRegion>Sapporo Medical University School of Medicine</wicri:noRegion></affiliation></author><author><name sortKey="Torigoe, Toshihiko" sort="Torigoe, Toshihiko" uniqKey="Torigoe T" first="Toshihiko" last="Torigoe">Toshihiko Torigoe</name><affiliation wicri:level="1"><country xml:lang="fr">Japon</country><wicri:regionArea>Department of Pathology, Sapporo Medical University School of Medicine</wicri:regionArea><wicri:noRegion>Sapporo Medical University School of Medicine</wicri:noRegion></affiliation></author><author><name sortKey="Itoh, Kyogo" sort="Itoh, Kyogo" uniqKey="Itoh K" first="Kyogo" last="Itoh">Kyogo Itoh</name><affiliation wicri:level="1"><country xml:lang="fr">Japon</country><wicri:regionArea>Department of Immunology and Immunotherapy, Kurume University School of Medicine</wicri:regionArea><wicri:noRegion>Kurume University School of Medicine</wicri:noRegion></affiliation></author><author><name sortKey="Patel, Prabhu S" sort="Patel, Prabhu S" uniqKey="Patel P" first="Prabhu S" last="Patel">Prabhu S. Patel</name><affiliation wicri:level="1"><country xml:lang="fr">Inde</country><wicri:regionArea>The Gujarat Cancer and Research Institute, Asarwa, Ahmedabad</wicri:regionArea><wicri:noRegion>Ahmedabad</wicri:noRegion></affiliation></author><author><name sortKey="Shukla, Shilin N" sort="Shukla, Shilin N" uniqKey="Shukla S" first="Shilin N" last="Shukla">Shilin N. Shukla</name><affiliation wicri:level="1"><country xml:lang="fr">Inde</country><wicri:regionArea>The Gujarat Cancer and Research Institute, Asarwa, Ahmedabad</wicri:regionArea><wicri:noRegion>Ahmedabad</wicri:noRegion></affiliation></author><author><name sortKey="Wang, Yili" sort="Wang, Yili" uniqKey="Wang Y" first="Yili" last="Wang">Yili Wang</name><affiliation wicri:level="1"><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>Institute for Cancer Research, Centre of Translational Medicine, Xi'an Jiaotong University, Xian</wicri:regionArea><wicri:noRegion>Xian</wicri:noRegion></affiliation></author><author><name sortKey="Kopetz, Scott" sort="Kopetz, Scott" uniqKey="Kopetz S" first="Scott" last="Kopetz">Scott Kopetz</name><affiliation wicri:level="3"><country xml:lang="fr">États-Unis</country><wicri:regionArea>MD Anderson Cancer Center, TX, Houston</wicri:regionArea><placeName><settlement type="city">Houston</settlement><region type="state">Texas</region></placeName></affiliation></author><author><name sortKey="Sinicrope, Frank A" sort="Sinicrope, Frank A" uniqKey="Sinicrope F" first="Frank A" last="Sinicrope">Frank A. Sinicrope</name><affiliation wicri:level="1"><country xml:lang="fr">États-Unis</country><wicri:regionArea>Mayo Clinic and Mayo College of Medicine, MN, 55905, Rochester</wicri:regionArea><wicri:noRegion>Rochester</wicri:noRegion></affiliation></author><author><name sortKey="Scripcariu, Viorel" sort="Scripcariu, Viorel" uniqKey="Scripcariu V" first="Viorel" last="Scripcariu">Viorel Scripcariu</name><affiliation wicri:level="1"><country xml:lang="fr">Roumanie</country><wicri:regionArea>Department of Surgery, University of Medicine and Pharmacy ‘Gr T Popa’, Department of Surgical Oncology, Regional Institute of Oncology, Iaşi</wicri:regionArea><wicri:noRegion>Iaşi</wicri:noRegion></affiliation></author><author><name sortKey="Ascierto, Paolo A" sort="Ascierto, Paolo A" uniqKey="Ascierto P" first="Paolo A" last="Ascierto">Paolo A. Ascierto</name><affiliation wicri:level="1"><country xml:lang="fr">Italie</country><wicri:regionArea>Medical Oncology and Innovative Therapies Unit, Istituto Nazionale per lo Studio e la Cura dei Tumouri, Fondazione ‘G Pascale’, Napoli</wicri:regionArea><wicri:noRegion>Napoli</wicri:noRegion></affiliation></author><author><name sortKey="Marincola, Francesco M" sort="Marincola, Francesco M" uniqKey="Marincola F" first="Francesco M" last="Marincola">Francesco M. Marincola</name><affiliation wicri:level="1"><country xml:lang="fr">Qatar</country><wicri:regionArea>Research Branch, Sidra Medical and Research Centre, Doha</wicri:regionArea><wicri:noRegion>Doha</wicri:noRegion></affiliation></author><author><name sortKey="Fox, Bernard A" sort="Fox, Bernard A" uniqKey="Fox B" first="Bernard A" last="Fox">Bernard A. Fox</name><affiliation wicri:level="2"><country xml:lang="fr">États-Unis</country><wicri:regionArea>Laboratory of Molecular and Tumour Immunology, Earle A. Chiles Research Institute, Robert W. Franz Cancer Center, Providence Portland Medical Center, Portland, OR</wicri:regionArea><placeName><region type="state">Oregon</region></placeName></affiliation><affiliation wicri:level="3"><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Molecular Microbiology and Immunology, Oregon Health and Science University, OR, Portland</wicri:regionArea><placeName><settlement type="city">Portland</settlement><region type="state">Oregon</region></placeName></affiliation></author><author><name sortKey="Pages, Franck" sort="Pages, Franck" uniqKey="Pages F" first="Franck" last="Pagès">Franck Pagès</name><affiliation wicri:level="3"><country xml:lang="fr">France</country><wicri:regionArea>INSERM, U872, Laboratory of Integrative Cancer Immunology, Paris</wicri:regionArea><placeName><region type="region">Île-de-France</region><region type="old region">Île-de-France</region><settlement type="city">Paris</settlement></placeName></affiliation><affiliation wicri:level="4"><country xml:lang="fr">France</country><wicri:regionArea>Université Paris Descartes, Paris</wicri:regionArea><placeName><region type="region">Île-de-France</region><region type="old region">Île-de-France</region><settlement type="city">Paris</settlement><settlement type="city">Paris</settlement></placeName><orgName type="university">Université Paris-Descartes</orgName></affiliation><affiliation wicri:level="1"><country xml:lang="fr">France</country><wicri:regionArea>Centre de Recherche des Cordeliers, Université Pierre et Marie Curie Paris 6</wicri:regionArea><wicri:noRegion>Université Pierre et Marie Curie Paris 6</wicri:noRegion><wicri:noRegion>Université Pierre et Marie Curie Paris 6</wicri:noRegion></affiliation><affiliation wicri:level="3"><country xml:lang="fr">France</country><wicri:regionArea>Immunomonitoring Platform, Laboratory of Immunology, Georges Pompidou European Hospital, Paris</wicri:regionArea><placeName><region type="region">Île-de-France</region><region type="old region">Île-de-France</region><settlement type="city">Paris</settlement></placeName></affiliation></author></analytic><monogr></monogr><series><title level="j" type="main">The Journal of Pathology</title><title level="j" type="alt">THE JOURNAL OF PATHOLOGY</title><idno type="ISSN">0022-3417</idno><idno type="eISSN">1096-9896</idno><imprint><biblScope unit="vol">232</biblScope><biblScope unit="issue">2</biblScope><biblScope unit="page" from="199">199</biblScope><biblScope unit="page" to="209">209</biblScope><biblScope unit="page-count">11</biblScope><publisher>John Wiley & Sons, Ltd</publisher><pubPlace>Chichester, UK</pubPlace><date type="published" when="2014-01">2014-01</date></imprint><idno type="ISSN">0022-3417</idno></series></biblStruct></sourceDesc><seriesStmt><idno type="ISSN">0022-3417</idno></seriesStmt></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract">The American Joint Committee on Cancer/Union Internationale Contre le Cancer (AJCC/UICC) TNM staging system provides the most reliable guidelines for the routine prognostication and treatment of colorectal carcinoma. This traditional tumour staging summarizes data on tumour burden (T), the presence of cancer cells in draining and regional lymph nodes (N) and evidence for distant metastases (M). However, it is now recognized that the clinical outcome can vary significantly among patients within the same stage. The current classification provides limited prognostic information and does not predict response to therapy. Multiple ways to classify cancer and to distinguish different subtypes of colorectal cancer have been proposed, including morphology, cell origin, molecular pathways, mutation status and gene expression‐based stratification. These parameters rely on tumour‐cell characteristics. Extensive literature has investigated the host immune response against cancer and demonstrated the prognostic impact of the in situ immune cell infiltrate in tumours. A methodology named ‘Immunoscore’ has been defined to quantify the in situ immune infiltrate. In colorectal cancer, the Immunoscore may add to the significance of the current AJCC/UICC TNM classification, since it has been demonstrated to be a prognostic factor superior to the AJCC/UICC TNM classification. An international consortium has been initiated to validate and promote the Immunoscore in routine clinical settings. The results of this international consortium may result in the implementation of the Immunoscore as a new component for the classification of cancer, designated TNM‐I (TNM‐Immune). © 2013 The Authors. Journal of Pathology published by John Wiley & Sons Ltd on behalf of Pathological Society of Great Britain and Ireland.</div></front></TEI><affiliations><list><country><li>Allemagne</li><li>Australie</li><li>Autriche</li><li>Canada</li><li>Espagne</li><li>France</li><li>Inde</li><li>Italie</li><li>Japon</li><li>Pays-Bas</li><li>Qatar</li><li>Roumanie</li><li>Royaume-Uni</li><li>République populaire de Chine</li><li>République tchèque</li><li>Suisse</li><li>Suède</li><li>États-Unis</li></country><region><li>Bohême centrale</li><li>Canton de Berne</li><li>Communauté de Madrid</li><li>Lombardie</li><li>Massachusetts</li><li>Oregon</li><li>Région de Kantō</li><li>Svealand</li><li>Texas</li><li>Victoria (État)</li><li>Île-de-France</li></region><settlement><li>Berne</li><li>Bobigny</li><li>Boston</li><li>Houston</li><li>Madrid</li><li>Melbourne</li><li>Milan</li><li>Paris</li><li>Portland</li><li>Prague</li><li>Stockholm</li><li>Tokyo</li></settlement><orgName><li>Université Paris-Descartes</li><li>Université de Berne</li><li>Université de Melbourne</li></orgName></list><tree><country name="France"><region name="Île-de-France"><name sortKey="Galon, Jerome" sort="Galon, Jerome" uniqKey="Galon J" first="Jérôme" last="Galon">Jérôme Galon</name></region><name sortKey="Angell, Helen K" sort="Angell, Helen K" uniqKey="Angell H" first="Helen K" last="Angell">Helen K. Angell</name><name sortKey="Angell, Helen K" sort="Angell, Helen K" uniqKey="Angell H" first="Helen K" last="Angell">Helen K. Angell</name><name sortKey="Angell, Helen K" sort="Angell, Helen K" uniqKey="Angell H" first="Helen K" last="Angell">Helen K. Angell</name><name sortKey="Berger, Anne" sort="Berger, Anne" uniqKey="Berger A" first="Anne" last="Berger">Anne Berger</name><name sortKey="Bindea, Gabriela" sort="Bindea, Gabriela" uniqKey="Bindea G" first="Gabriela" last="Bindea">Gabriela Bindea</name><name sortKey="Bindea, Gabriela" sort="Bindea, Gabriela" uniqKey="Bindea G" first="Gabriela" last="Bindea">Gabriela Bindea</name><name sortKey="Bindea, Gabriela" sort="Bindea, Gabriela" uniqKey="Bindea G" first="Gabriela" last="Bindea">Gabriela Bindea</name><name sortKey="Galon, Jerome" sort="Galon, Jerome" uniqKey="Galon J" first="Jérôme" last="Galon">Jérôme Galon</name><name sortKey="Galon, Jerome" sort="Galon, Jerome" uniqKey="Galon J" first="Jérôme" last="Galon">Jérôme Galon</name><name sortKey="Galon, Jerome" sort="Galon, Jerome" uniqKey="Galon J" first="Jérôme" last="Galon">Jérôme Galon</name><name sortKey="Lagorce, Christine" sort="Lagorce, Christine" uniqKey="Lagorce C" first="Christine" last="Lagorce">Christine Lagorce</name><name sortKey="Mlecnik, Bernhard" sort="Mlecnik, Bernhard" uniqKey="Mlecnik B" first="Bernhard" last="Mlecnik">Bernhard Mlecnik</name><name sortKey="Mlecnik, Bernhard" sort="Mlecnik, Bernhard" uniqKey="Mlecnik B" first="Bernhard" last="Mlecnik">Bernhard Mlecnik</name><name sortKey="Mlecnik, Bernhard" sort="Mlecnik, Bernhard" uniqKey="Mlecnik B" first="Bernhard" last="Mlecnik">Bernhard Mlecnik</name><name sortKey="Pages, Franck" sort="Pages, Franck" uniqKey="Pages F" first="Franck" last="Pagès">Franck Pagès</name><name sortKey="Pages, Franck" sort="Pages, Franck" uniqKey="Pages F" first="Franck" last="Pagès">Franck Pagès</name><name sortKey="Pages, Franck" sort="Pages, Franck" uniqKey="Pages F" first="Franck" last="Pagès">Franck Pagès</name><name sortKey="Pages, Franck" sort="Pages, Franck" uniqKey="Pages F" first="Franck" last="Pagès">Franck Pagès</name></country><country name="Suisse"><region name="Canton de Berne"><name sortKey="Lugli, Alessandro" sort="Lugli, Alessandro" uniqKey="Lugli A" first="Alessandro" last="Lugli">Alessandro Lugli</name></region><name sortKey="Zlobec, Inti" sort="Zlobec, Inti" uniqKey="Zlobec I" first="Inti" last="Zlobec">Inti Zlobec</name></country><country name="Allemagne"><noRegion><name sortKey="Hartmann, Arndt" sort="Hartmann, Arndt" uniqKey="Hartmann A" first="Arndt" last="Hartmann">Arndt Hartmann</name></noRegion></country><country name="États-Unis"><region name="Oregon"><name sortKey="Bifulco, Carlo" sort="Bifulco, Carlo" uniqKey="Bifulco C" first="Carlo" last="Bifulco">Carlo Bifulco</name></region><name sortKey="Fox, Bernard A" sort="Fox, Bernard A" uniqKey="Fox B" first="Bernard A" last="Fox">Bernard A. Fox</name><name sortKey="Fox, Bernard A" sort="Fox, Bernard A" uniqKey="Fox B" first="Bernard A" last="Fox">Bernard A. Fox</name><name sortKey="Kopetz, Scott" sort="Kopetz, Scott" uniqKey="Kopetz S" first="Scott" last="Kopetz">Scott Kopetz</name><name sortKey="Ogino, Shuji" sort="Ogino, Shuji" uniqKey="Ogino S" first="Shuji" last="Ogino">Shuji Ogino</name><name sortKey="Sinicrope, Frank A" sort="Sinicrope, Frank A" uniqKey="Sinicrope F" first="Frank A" last="Sinicrope">Frank A. Sinicrope</name></country><country name="Pays-Bas"><noRegion><name sortKey="Nagtegaal, Iris D" sort="Nagtegaal, Iris D" uniqKey="Nagtegaal I" first="Iris D" last="Nagtegaal">Iris D. Nagtegaal</name></noRegion></country><country name="Suède"><noRegion><name sortKey="Palmqvist, Richard" sort="Palmqvist, Richard" uniqKey="Palmqvist R" first="Richard" last="Palmqvist">Richard Palmqvist</name></noRegion><name sortKey="Masucci, Giuseppe V" sort="Masucci, Giuseppe V" uniqKey="Masucci G" first="Giuseppe V" last="Masucci">Giuseppe V. Masucci</name></country><country name="Italie"><noRegion><name sortKey="Botti, Gerardo" sort="Botti, Gerardo" uniqKey="Botti G" first="Gerardo" last="Botti">Gerardo Botti</name></noRegion><name sortKey="Ascierto, Paolo A" sort="Ascierto, Paolo A" uniqKey="Ascierto P" first="Paolo A" last="Ascierto">Paolo A. 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Marincola</name></country><country name="Canada"><noRegion><name sortKey="Ohashi, Pamela S" sort="Ohashi, Pamela S" uniqKey="Ohashi P" first="Pamela S" last="Ohashi">Pamela S. Ohashi</name></noRegion><name sortKey="Hafezi Akhtiari, Sara" sort="Hafezi Akhtiari, Sara" uniqKey="Hafezi Akhtiari S" first="Sara" last="Hafezi-Bakhtiari">Sara Hafezi-Bakhtiari</name><name sortKey="Nguyen, Linh" sort="Nguyen, Linh" uniqKey="Nguyen L" first="Linh" last="Nguyen">Linh Nguyen</name><name sortKey="Roehrl, Michael" sort="Roehrl, Michael" uniqKey="Roehrl M" first="Michael" last="Roehrl">Michael Roehrl</name><name sortKey="Wouters, Bradly G" sort="Wouters, Bradly G" uniqKey="Wouters B" first="Bradly G" last="Wouters">Bradly G. Wouters</name></country><country name="Japon"><region name="Région de Kantō"><name sortKey="Kawakami, Yutaka" sort="Kawakami, Yutaka" uniqKey="Kawakami Y" first="Yutaka" last="Kawakami">Yutaka Kawakami</name></region><name sortKey="Hazama, Shoichi" sort="Hazama, Shoichi" uniqKey="Hazama S" first="Shoichi" last="Hazama">Shoichi Hazama</name><name sortKey="Itoh, Kyogo" sort="Itoh, Kyogo" uniqKey="Itoh K" first="Kyogo" last="Itoh">Kyogo Itoh</name><name sortKey="Okuno, Kiyotaka" sort="Okuno, Kiyotaka" uniqKey="Okuno K" first="Kiyotaka" last="Okuno">Kiyotaka Okuno</name><name sortKey="Sato, Noriyuki" sort="Sato, Noriyuki" uniqKey="Sato N" first="Noriyuki" last="Sato">Noriyuki Sato</name><name sortKey="Torigoe, Toshihiko" sort="Torigoe, Toshihiko" uniqKey="Torigoe T" first="Toshihiko" last="Torigoe">Toshihiko Torigoe</name></country><country name="Australie"><noRegion><name sortKey="Gibbs, Peter" sort="Gibbs, Peter" uniqKey="Gibbs P" first="Peter" last="Gibbs">Peter Gibbs</name></noRegion><name sortKey="Waring, Paul" sort="Waring, Paul" uniqKey="Waring P" first="Paul" last="Waring">Paul Waring</name></country><country name="Inde"><noRegion><name sortKey="Patel, Prabhu S" sort="Patel, Prabhu S" uniqKey="Patel P" first="Prabhu S" last="Patel">Prabhu S. Patel</name></noRegion><name sortKey="Shukla, Shilin N" sort="Shukla, Shilin N" uniqKey="Shukla S" first="Shilin N" last="Shukla">Shilin N. Shukla</name></country><country name="République populaire de Chine"><noRegion><name sortKey="Wang, Yili" sort="Wang, Yili" uniqKey="Wang Y" first="Yili" last="Wang">Yili Wang</name></noRegion></country><country name="Roumanie"><noRegion><name sortKey="Scripcariu, Viorel" sort="Scripcariu, Viorel" uniqKey="Scripcariu V" first="Viorel" last="Scripcariu">Viorel Scripcariu</name></noRegion></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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